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Dr. Josefina Piñón Hofbauer

Leiterin Arbeitsgruppe Piñón/Gruber

Wissenschaftliches Interesse

Dr. Piñón Hofbauer kann auf eine 12-jährige Erfahrung in der Onkologie und davon fünf Jahre in der EB-Krebsforschung zurückgreifen. Ihr wissenschaftliches Interesse spannt sich von Tumorbiologie und Immunologie, Signaltransduktion bis zu Tumormausmodellen.
Dr. Piñón Hofbauers Forschung konzentriert sich auf die Entwicklung von diagnostischen Tests und therapeutischen Strategien für Epidermolysis bullosa-assoziierten Plattenepithelkarzinomen.

Persönliche Interessen

Liebende Mutter, begeisterte Strickerin und Bastlerin, Reiseliebhaberin, Unter-der-Dusche-Karaoke-Sängerin

Curriculum Vitae Josefina Piñón Hofbauer

Berufliche Laufbahn

Seit 2014
Gruppenleiterin
, EB-Haus Austria

2013 - 2014
Senior Postdoc
, EB-Haus Austria

2005 - 2013
Senior Postdoc
, Labor für immunologische und molekulare Krebsforschung, Salzburg, Österreich

2001 - 2005
Postdoc
, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Schottland

2000 - 2001
Postdoc
, Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA

 

Akademische Laufbahn

1999
PhD
, in Molekularbiologie (Schwerpunkt: Mikrobiologie/Virologie), University of Pennsylvania School of Medicine, Philadelphia PA, USA

1992
BA
in Biologie, Mount Holyoke College, South Hadley MA, USA

 

Auszeichnungen und Stipendien

2016 Paracelsus Wissenschaftspreis der Paracelsus Medizinische Privatuniversität in Bronze
2012 Paracelsus Wissenschaftspreis der Paracelsus Medizinische Privatuniversität in Silver
2011 Sanofi Forsachungspreis zur Förderung der medizinischen Forschung in Österreich, Paracelsus Medizinische Privatuniversität
2011 Paracelsus Wissenschaftspreis der Paracelsus Medizinische Privatuniversität in Gold
2010 Wilhelm Türk-Preis der Österreichischen Gesellschaft für Hämatologie & Medizinische Onkologie (ÖGHO)

 

Internationale Forschungsaufenthalte

Humaner T-Zell-Leukämievirus (HTLV-I)-Eintritt in humane Zellen. Biomedical Research Center, University of Dundee, Dundee, Scotland

Pathogenese von rekombinaten murinen Hepatitisviren; Polyproteinverarbeitung in Gen 1 von Coronavirus MHV-A59. Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA

Untersuchung der Transkriptionsinitiationsrate im stabilen RNA argT Promoter. Department of Biochemistry, Mount Holyoke College, South Hadley, MA, USA

 

Sonstige Qualifikationen/Weiterbildungen

2017 Laborführungskurs für Gruppenleiter, European Molecular Biology Organization (EMBO), Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Leimen, Heidelberg, Deutschland
2015 LSR Fortessa Durchflusszytometrie-Kurs, Becton Dickinson, Salzburg, Österreich
2010 Galios Durchflusszytometrie-Kurs, Beckman Coulter, Salzburg, Österreich

Originalartikel

  1. March OP, Lettner T, Klausegger A, Ablinger M, Kocher T, Hainzl S, Peking P, Lackner N, Rajan N, Hofbauer JP, Guttmann-Gruber C, Bygum A, Koller U, Reichelt J.  Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes. J Invest Dermatol. 2019 Aug;139(8):1699-1710.e6. doi: 10.1016/j.jid.2019.03.1146. Epub 2019 Apr 15.
  2. Sun Y*, Piñón Hofbauer J*, Harada M, Wöss K, Koller U, Morio H, Stierschneider A, Kitamura K, Hashimoto M, Chiba K, Akita H, Anzai N, Reichelt J, Bauer JW, Guttmann-Gruber C*, Furihata T*. Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology. Cancer Lett. 2018 433:107-116. *equally contributing authors
  3. Fuentes I*, Guttmann-Gruber C*, Tay AS*, Piñón Hofbauer J, Denil S, Reichelt J, Palisson F, Common JE, South AP. Reduced microbial diversity is a feature of recessive dystrophic epidermolysis bullosa involved skin and wounds. J Invest Dermatol 2018 accepted manuscript. *equally contributing authors
  4. Liemberger B, Piñón Hofbauer J, Wally V, Arzt C, Hainzl S, Kocher T, Murauer EM, Bauer JW, Reichelt J, and Koller U. RNA Trans-Splicing Modulation via Antisense Molecule Interference. Int J Mol Sci 2018;19:762.
  5. Morio H, Sun Y, Harada M, Ide H, Shimozato O, Zhou X, Higashi K, Yuki R, Yamaguchi N, Piñón Hofbauer J, Guttmann-Gruber C, Anzai N, Akita H, Chiba K, and Furihata T. Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker. Biol Pharm Bull 2018;41:445-449.
  6. Sun Y, Woess K, Kienzl M, Leb-Reichl VM, Feinle A, Wimmer M, Zauner R, Wally V, Luetz-Meindl U, Mellerio JE, Fuentes I, South AP, Bauer JW, Reichelt J, Furihata T, Guttmann-Gruber C, and Piñón Hofbauer J. Extracellular Vesicles as Biomarkers for the Detection of a Tumor Marker Gene in Epidermolysis Bullosa-Associated Squamous Cell Carcinoma. J Invest Dermatol 2017;12
  7. Kocher T, Peking P, Klausegger A, Murauer EM, Piñón Hofbauer J, Wally V, Lettner T, Hainzl S, Ablinger M, Bauer JW, Reichelt J, and Koller U. Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases. Mol Ther 2017;25:2585-2598.
  8. Atanasova VS, Jiang Q, Prisco M, Gruber C, Piñón Hofbauer J, Chen M, Has C, Bruckner-Tuderman L, McGrath JA, Uitto J, and South AP. Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. J Invest Dermatol 2017;137:1842-1849.
  9. Zaborsky N, Gassner FJ, Asslaber D, Reinthaler P, Denk U, Flenady S, Piñón Hofbauer J, Danner B, Rebhandl S, Harrer A, Geisberger R, Greil R, and Egle A. CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells. Oncotarget 2016;7:49459-49469.
  10. Kocher T, Asslaber D, Zaborsky N, Flenady S, Denk U, Reinthaler P, Ablinger M, Geisberger R, Bauer JW, Seiffert M, Hartmann TN, Greil R, Egle A, and Piñón Hofbauer J. CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model. Leukemia 2016;30:1409-1413.
  11. Hofbauer SW, Krenn PW, Piñón Hofbauer J, Pucher S, Asslaber D, Egle A, Hartmann TN, Greil R. The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells. Br J Haematol 2016;172(5):815-9.
  12. Zaborsky N, Holler C, Geisberger R, Asslaber D, Gassner FJ, Egger V, Piñón Hofbauer J, Kocher T, Hartmann TN, Greil R, and Egle A. B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia. Haematologica 2015;100:e307-e310.
  13. Grössinger E,Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón Hofbauer J, Hartmann TN, Greil R, and Kerschbaum H. Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade. Leukemia 2014;28:954-958.
  14. Valente LJ, Gray DHD, Michalak EM, Piñón Hofbauer J, Egle A, Scott CL, Janic A, and Strasser A. p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep 2013;3:1339-1345.
  15. Merkel O, Wacht N, Sifft E, Melchardt T, Hamacher F, Kocher T, Denk U, Piñón Hofbauer J, Egle A, Scheideler M, Schlederer M, Steurer M, Kenner L, and Greil R. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia 2012;26:2508-2516.
  16. Piñón Hofbauer J, Heyder C, Denk U, Kocher T, Holler C, Trapin D, Asslaber D, Tinhofer I, Greil R, and Egle A. Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL. Leukemia 2011;25:1452-1458.
  17. Gassner FJ, Weiss L, Geisberger R, Piñón Hofbauer J, Egle A, Hartmann TN, Greil R, and Tinhofer I. Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia. Cancer Immunol Immunother 2011;60:75-85.
  18. Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Piñón Hofbauer J, Egle A, Greil R, and Hartmann TN. Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells. PloS one 2011;6:e23758.
  19. Hofbauer SW, Piñón JD, Brachtl G, Haginger L, Wang W, Jöhrer K, Tinhofer I, Hartmann TN, and Greil R. Modifying akt signaling in B-cell chronic lymphocytic leukemia cells. Cancer Res 2010;70:7336-7344.
  20. Merkel O, Asslaber D, Piñón JD, Egle A, and Greil R. Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia. Cell cycle 2010;9:2764-2768.
  21. Asslaber D, Piñón JD, Seyfried I, Desch P, Stöcher M, Tinhofer I, Egle A, Merkel O, and Greil R. microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia. Blood 2010;115:4191-4197.
  22. Holler C, Piñón JD, Denk U, Heyder C, Hofbauer S, Greil R, and Egle A. PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood 2009;113:2791-2794.
  23. Piñón JD, Klasse PJ, Jassal SR, Welson S, Weber J, Brighty DW, and Sattentau QJ. Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans. J Virol 2003;77:9922-9930.
  24. Piñón JD, Kelly SM, Price NC, Flanagan JU, and Brighty DW. An antiviral peptide targets a coiled-coil domain of the human T-cell leukemia virus envelope glycoprotein. J Virol 2003;77:3281-3290.
  25. Tsai JC, Groot L de, Piñón JD, Iacono KT, Phillips JJ, Seo Sh, Lavi E, and Weiss SR. Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system. Virology 2003;312:369-380.
  26. De Groot L, Piñón JD, Phillips J, Lavi E, and Weiss SR. Pathogenesis of fusion deficient recombinant mouse hepatitis viruses. Adv Exp Med Biol 2001;494:159-162.
  27. Piñón JD, Teng H, and Weiss SR. Further requirements for cleavage by the murine coronavirus 3C-like proteinase: identification of a cleavage site within ORF1b. Virology 1999;263:471-484.
  28. Teng H, Piñón JD, and Weiss SR. Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. J Virol 1999;73:2658-2666.
  29. Bi W, Piñón JD, Hughes S, Bonilla PJ, Holmes KV, Weiss SR, and Leibowitz JL. Localization of mouse hepatitis virus open reading frame 1A derived proteins. J Neurovirol 1998;4:594-605.
  30. Piñón JD, Mayreddy RR, Turner JD, Khan FS, Bonilla PJ, and Weiss SR. Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from the flanking hydrophobic domains requires membranes. Virology 1997;230:309-322.
  31. Bonilla PJ, Hughes SA, Piñón JD, and Weiss SR. Characterization of the leader papain-like proteinase of MHV-A59: identification of a new in vitro cleavage site. Virology 1995;209:489-497.

Übersichtsarbeiten

  1. Brachtl G, Piñón Hofbauer J, Greil R, Hartmann TN. The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia. Ann Hematol 2014;93(3):361-74.
  2. Piñón JD, Labi V, Egle A, and Villunger A. Bim and Bmf in tissue homeostasis and malignant disease. Oncogene 2008;27 Suppl 1:S41-S52.

Wissenschaftliche Kommentare

  1. Gruber C, Piñón Hofbauer J, and Bauer JW. Can we be SMaRT-er in our approach to cancer therapy? EBioMedicine 2015;2. Original DateCompleted: 20150820:621-622.
  2. Egle A, Asslaber D, Villunger A, and Piñón Hofbauer J. Bid-ding for mercy: twisted killer in action. Cell Death Differ 2013;20:847-849.
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