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Victoria Reichl, PhD

Postdoc

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Research statement

I am interested in the development of an immunotherapy against cutaneous squamous cell carcinoma (cSCC) which is very aggressive and arises at a higher frequency in recessive dystrophic epidermolysis bullosa (RDEB) patients. Currently, surgery over a wide area represents the primary treatment option due to the metastasizing nature of the tumor.
We believe that cancer immunotherapy represents a promising adjuvant therapy to control or even eliminate RDEB cSCC and therefore, we want to take advantage of the preexisting immune system to fight cancer.

Curriculum Vitae Victoria Reichl

Professional Career

Since 2012
Postdoc at the EB House Austria

2009-2011
Postdoc at the Christian Doppler Laboratory for Immunomodulation, Institute of Immunology, Medical University of Vienna (MUV)

 

Education

2003-2009
PhD in Medical Sciences at the Medical University of Vienna (MUV)
"Influencing the allergenspecific immune response at the level of antigen presentation using Anergosomes for allergen-specific anergisation"
Research group: Ao. Univ.-Prof. Dr. Winfried Pickl

1997-2003
MSc in biology/genetics at the Paris Lodron University Salzburg
"Development of an automated LightCyclerPCR Assay for the quantitative detection of HBV-DNA in clinical specimen complemented with an internal amplification control as PCR competitor"
Research groups: Univ. Doz. Dr. Jörg Berg (AKH Linz), Ao.Univ.-Prof. Dr Josef Thalhamer (University of Salzburg)

 

Awards and Fellowships

2009 Clemens von Pirquet Prize of the Austrian Society of Allergology and Immunology (ÖGAI)
2009 ÖGAI-Posterprize of the Austrian Society of Allergology and Immunology (ÖGAI)
2006 Travel grant of the European Federation of Immunological Societies (EFIS) for attendance of the 7th EFIS Tatra Immunology Conference, Strbské Pleso, Slovakia
2005 Travel grant of the European Federation of Immunological Societies (EFIS) for attendance of the 6th EFIS Tatra Immunology Conference, Tatranské Zruby, Slovakia

 

Additional Qualifications/Training

Filemaker administrator at the EB House Austria
Course in Basics of Laboratory Animal Science according to FELASA Cat. B, Medical University Graz (MUG)
GCP - Good Clinical Practice - Introduction in Clinical Trials, Clinical Research Center Salzburg (CRCS)
§§26 and 27-projects: Framework conditions, fundamentals and processes in the management of third-party funded projects, MedUni Vienna
Project management, MedUni Vienna

Original articles

  1. Welponer T, Weber DD, Trattner L, Tockner B, Aminzadeh-Gohari S, Leb-Reichl V, Kaufmann A, Zauner R, Wimmer M, Wally V, Felder TK, Strunk D, Koller U, Bauer JW, Kofler B, Guttmann-Gruber C, Piñon Hofbauer J. Metformin shows anti-neoplastic properties by inhibition of oxidative phosphorylation and glycolysis in epidermolysis bullosa-associated aggressive cutaneous squamous cell carcinoma. Journal of the European Academy of Dermatology and Venereology : JEADV 2023
  2. Bischof J, March OP, Liemberger B, Haas SA, Hainzl S, Petković I, Leb-Reichl V, Illmer J, Korotchenko E, Klausegger A, Hoog A, Binder H-M, Garcia M, Duarte B, Strunk D, Larcher F, Reichelt J, Guttmann-Gruber C, Wally V, Hofbauer JP, Bauer JW, Cathomen T, Kocher T, Koller U. Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa. Molecular Therapy 2022.
  3. Woess K, Sun Y, Morio H, Stierschneider A, Kaufmann A, Hainzl S, Trattner L, Kocher T, Tockner B, Leb-Reichl V, Steiner M, Brachtl G, South AP, Bauer JW, Reichelt J, Furihata T, Wally V, Koller U, Piñón Hofbauer J, Guttmann-Gruber C. Evaluating a Targeted Cancer Therapy Approach Mediated by RNA trans-Splicing In Vitro and in a Xenograft Model for Epidermolysis Bullosa-Associated Skin Cancer. International journal of molecular sciences 2022;23.
  4. Guttmann-Gruber C, Piñón Hofbauer J, Tockner B, Reichl V, Klausegger A, Hofbauer P, Wolkersdorfer M, Tham KC, Lim SS, Common JE, Diem A, Ude-Schoder K, Hitzl W, Lagler F, Reichelt J, Bauer JW, Lang R, Laimer M. Impact of low-dose calcipotriol ointment on wound healing, pruritus and pain in patients with dystrophic epidermolysis bullosa: A randomized, double-blind, placebo-controlled trial. Orphanet J Rare Dis 2021;16:473.
  5. Neunkirchner A, Kratzer B, Köhler C, Smole U, Mager LF, Schmetterer KG, Trapin D, Leb-Reichl V, Rosloniec E, Naumann R, Kenner L, Jahn-Schmid B, Bohle B, Valenta R, Pickl WF. Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice. EBioMedicine 2018; pii: S2352-3964(18)30122-1. doi: 10.1016/j.ebiom.2018.04.001.
  6. Sun Y, Woess K, Kienzl M, Leb-Reichl VM, Feinle A, Wimmer M, Zauner R, Wally V, Luetz-Meindl U, Mellerio JE, Fuentes I, South AP, Bauer JW, Reichelt J, Furihata T, Guttmann-Gruber C, Piñón Hofbauer J. Extracellular vesicles as biomarkers for the detection of a novel tumor marker gene in epidermolysis bullosa-associated squamous cell carcinoma. J Invest Dermatol 2017; pii: S0022-202X(17)33230-X. doi: 10.1016/j.jid.2017.11.022.
  7. Van Hemelen D, Mahler V, Fischer G, Fae I, Reichl-Leb V, Pickl W, Jutel M, Smolinska S, Ebner C, Bohle B, Jahn-Schmid B. HLA class II peptide tetramers vs alleren-induced proliferaton for identification of allergen-specific CD4 T cells. Allergy 2015;70(1): 49-58; doi: 10.1111/all.12524
  8. Neunkirchner A, Leb-Reichl VM, Schmetterer KG, Mutschlechner S, Kueng HJ, Haiderer D, Schuch K, Wallner M, Jahn-Schmid B, Bohle B, Pickl WF. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1- specific Th2 cells. J Immunol 2011;187(8): 4077-87. doi: 10.4049/jimmunol.1003220.
  9. Schmetterer KG, Haiderer D, Leb-Reichl VM, Neunkirchner A, Jahn-Schmid B, Kueng HJ, Schuch K, Steinberger P, Bohle B, Pickl WF. Bet v 1-specific TCR/Foxp3 transgenic T cells suppress Bet v 1-specific T cell effector function in an activation dependent manner. J Allergy Clin Immunol 2011;127(1): 238-45, 245.e1-3. doi: 10.1016/j.jaci.2010.10.023
  10. Kueng HJ, Manta C, Haiderer D, Leb VM, Schmetterer KG, Neunkirchner A, Byrne RA, Scheinecker C, Steinberger P, Seed B, Pickl WF. Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions. FASEB 2010;24(5): 1572-82. doi: 10.1096/fj.09-137281
  11. Leb VM, Jahn-Schmid B, Kueng HJ, Schmetterer KG, Haiderer D, Neunkirchner A, Fischer GF, Hartl A, Thalhamer J, Steinberger P, Bohle B, Seed B, Pickl WF. Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules. J Allergy Clin Immunol 2009;124(1):121-8. doi: 10.1016/j.jaci.2009.04.008.
  12. Jahn-Schmid B, Sirven P, Leb V, Pickl WF, Fischer GF, Gadermaier G, Egger M, Ebner C, Ferreira F, Maillére B, Bohle B. Characterization of HLA class II/peptide-TCR interactions of the immunodominant T cell epitope in Art v 1, the major mugwort pollen allergen. J Immunol 2008;181(5): 3636-42.
  13. Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF. Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes. J Allergy Clin Immunol. 2008;121(1):64-71
  14. Kueng HJ, Leb VM, Haiderer D, Raposo G, Thery C, Derdak SV, Schmetterer KG, Neunkirchner A, Sillaber C, Seed B, Pickl WF. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J Virol 2007;81(16):8666-76 doi:10.1128/JVI.00682-07
  15. Derdak SV, Kueng HJ, Leb VM, Neunkirchner A, Schmetterer KG, Bielek E, Majdic O, Knapp W, Seed B, Pickl WF. Direct stimulation of T lymphocytes by immunosomes: virus like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules. Proc Natl Acad Sci USA 2006;103(35):13144-9 doi: 10.1073/pnas.0602283103
  16. Leb V, Stocher M, Valentine-Thon E, Holzl G, Kessler H, Stekel H, Berg J. Fully automated, internally controlled quantification of hepatitis B Virus DNA by real-time PCR by use of the MagNA Pure LC and LightCycler instruments. J Clin Microbiol 2004;42(2):585-90
  17. Holzl G, Stocher M, Leb V, Stekel H, Berg J. Entirely automated quantification of human immunodeficiency virus type 1 (HIV-1) RNA in plasma by using the ultrasensitive COBAS AMPLICOR HIV-1 monitor test and RNA purification on the MagNA Pure LC instrument. J Clin Microbiol 2003;41(3):1248-51
  18. Stocher M, Leb V, Bozic M, Kessler HH, Halwachs-Baumann G, Landt O, Stekel H, Berg J. Parallel detection of five human herpes virus DNAs by a set of real-time polymerase chain reactions in a single run., J Clin Virol 2003;26(1):85-93
  19. Stocher M, Leb V, Berg J. A convenient approach to the generation of multiple internal control DNA for a panel of real-time PCR assays. J Virol Methods 2003;108(1):1-8
  20. Stocher M, Leb V, Holzl G, Berg J. A simple approach to the generation of heterologous competitive internal controls for real-time PCR assays on the LightCycler. J Clin Virol 2002;25 Suppl 3:47-53
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