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Johannes Bischof, PhD


Research statement

I am interested in epidermis and dermis. Until now I was mostly working in the field of skin aging and aging in general. From now on my time will be dedicated to skin disorders, especially to different forms of Epidermolysis bullosa. The most important method employed will be AON-induced exon skipping.

Personal interests

In my spare time I like to go climbing and play board games.

Curriculum Vitae Johannes Bischof

Professional Career

Since 2018
Postdoc at the EB House Austria

Project work for L'Oréal, Paris Lodron University Salzburg

Project work for Stratec Consumables, SALK



Dr. rer. nat.
in Genetics, Paris Lodron University Salzburg

in Genetics, Paris Lodron University Salzburg

Bakk. rer. nat.
in Genetics, Paris Lodron University Salzburg


Additional qualifications/training

Project management course

Original Articles

  1. Kocher T, Bischof J, Haas SA, March OP, Liemberger B, Hainzl S, Illmer J, Hoog A, Muigg K, Binder HM, Klausegger A, Strunk D, Bauer JW, Cathomen T, Koller U. A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa. Molecular Therapy - Nucleic Acids, 2021
  2. Bornert O, Hogervorst M, Nauroy P, Bischof J, Swildens J, Athanasiou I, Tufa SF, Keene DR, Kiritsi D, Hainzl S, Murauer EM, Marinkovich MP, Platenburg G, Hausser I, Wally V, Ritsema T, Koller U, Haisma EM, Nyström A. QR-313, an Antisense Oligonucleotide, Shows Therapeutic Efficacy for Treatment of Dominant and Recessive Dystrophic Epidermolysis Bullosa: A Preclinical Study. J Invest Dermatol
  3. Kocher T, March OP, Bischof J, Liemberger B, Hainzl S, Klausegger A, Hoog A, Strunk D, Bauer JW, Koller U. Predictable CRISPR/Cas9-Mediated COL7A1 Reframing for Dystrophic Epidermolysis Bullosa. J Invest Dermatol. 2020, ISSN 0022-202X
  4. Rinnerthaler M, Duschl J, Steinbacher P, Salzmann M, Bischof J, Schuller M, Wimmer H, Peer T, Bauer JW, Richter K. Age-related changes in the composition of the cornified envelope in human skin. Exp. Dermatol. 2013;22(5):329-335.
  5. Bischof J, Salzmann M, Streubel M K, Hasek J, Geltinger F, Duschl J, Bresgen N, Briza P, Haskova D, Sopjani M, Richter K, Rinnerthaler M. Clearing the Outer Mitochondrial Membrane from harmful proteins via LipidDroplets. Cell Death Discov. 2017;3:17016
  6. Auer S, Rinnerthaler M, Bischof J, Streubel MK, Breitenbach-Koller L, Geisberger R, Aigner E, Cadamuro J, Richter K, Sopjani M, Haschke-Becher E, Felder TK, Breitenbach M. The Human NADPH Oxidase, Nox4, Regulates Cytoskeletal Organization in Two Cancer Cell Lines, HepG2 and SH-SY5Y. Front. Oncol. 2017;7(111).
  7. Streubel MK, Bischof J, Weiss R, Duschl J, Liedl W, Wimmer H, Breitenbach M, Weber M, Geltinger F, Richter K, Rinnerthaler M. Behead and live long or the tale of cathepsin L. Yeast 2018;35(2):237-249.
  8. Streubel MK, Neuhofer C, Bischof J, Steinbacher P, Russe E, Wechselberger G, Richter K, Rinnerthaler M. From Mice to Men: An Evolutionary Conserved Breakdown of the Epidermal Calcium Gradient and Its Impact on the Cornified Envelope. Cosmetics 2018;5(2):35.


  1. Kocher T, Petkovic I, Bischof J, Koller U. Current developments in gene therapy for epidermolysis bullosa. Expert opinion on biological therapy 2022:1-14.
  2. Rinnerthaler M, Streubel MK, Bischof J, Richter K. Skin Aging, gene expression and calcium. Exp. Gerontol. 2015;68:59-65.
  3. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules 2015;5(2):545-589.

Book Chapters

  1. Streubel MK, Rinnerthaler M, Bischof J, Richter K. Changes in the Composition of the Cornified Envelope During Skin Aging. Textbook of Aging Skin 2017;ISBN:978-3-662-47397-9.
  2. Bischof J. Lipid droplets im Kontext von zellulärem Stress. Gesund Altern 2018;ISBN: 978-3-658-19972-2.


  1. Kocher T, March OP, Bischof J, Liemberger B, Hainzl S, Klausegger A, Hoog A, Strunk D, Bauer JW, Koller U. CRISPR-Cas9-basierte Korrekturstrategie – vorhersagbare Reparaturergebnisse. Spectrum Dermatologie 2020;04/2020:62-3.

Teacher at a laboratory training course in the field of aging research at the Paris Lodron University Salzburg

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