Research statement
I was always fascinated by our immune system which so efficiently protect us from the constant attack of diverse army of microbes.
Currently, I am working as a Postdoctoral Researcher in the group of Dr. Iris Gratz. I am working on Epidermolysis Bullosa which is a group of rare genetic skin disorder. Our aim is to understand the role of systemic as well cutaneous immune cells in the process of wound healing in EB patients. We want to know if the tendency of EB wounds becoming chronic in naure could be attributed to dysfunctional immune cells. Our goal is to phenotypically as well functionally characterize various immune cell subsets in EB patients with and without squamous cell carcinomas. This study will provide us an insight into the immune cell dysregulation in cancerous conditions. We also hope to find predisposing conditions that might be responsible for chronic wounds to become cancerous in nature.
Personal interests
During my free time I like to make sketches or read fiction novels.
Curriculum Vitae Anshu Sharma
Professional career
Since 2019
Postdoctoral Researcher: Group of Dr. Iris Gratz (University of Salzburg, Salzburg, Austria)
Education
2011-2018
PhD: Biology, National Institute of Immunology, New Delhi, India
Title of PhD thesis: Exploring the immunoprophylactic potential of Mesenchymal Stem Cells for Type 1 Diabetes.
Supervisor: Dr. Rajni Rani
2009-2011
Master studies: Biochemistry, Hamdard University, New Delhi, India
Title of master thesis: Studies on the expression of Green Fluorescent Protein in bacteria.
Supervisor: Dr. Javed Ali
2006-2009
Bachelor studies: Biomedical Sciences, Delhi University, Delhi, India
Awards and Fellowships
Canadian Queen Elizabeth II Diamond Jubilee Scholarship
Senior Research Fellowship - National Institute of Immunology, New Delhi, India
Qualified Council of scientific and industrial research/University grant Commission (CSIR-UGC) National Eligibility Test (NET) for CSIR- JRF life sciences with 34th rank all over India.
Research proposal presentation in BIOSPARKS 2011, 9th Annual Reasearch Festival, School of Life Sciences, Jawaharlal Nehru University, India.
Graduate Aptitude Test in Engineering (GATE) 2011
Original articles
- Lesley A Ward, Dennis Sw Lee, Anshu Sharma, Angela Wang, Ikbel Naouar, Xianjie I Ma, Natalia Pikor, Barbara Nuesslein-Hildesheim, Valeria Ramaglia, Jennifer L Gommerman. Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury. JCI Insight. 2020 Jan 16;5(1):e132522.
- Dani P, Patnaik N, Singh A, Jaiswal A, Agarwal B, Kumar A, Varkhande S, Sharma A, Vaish U, Ghosh P, Sharma V, Sharma P, Verma G, Kar H, Gupta S, Natarajan V, Gokhale R & Rani R. Association and expression of antigen processing gene PSMB8 coding for Low Molecular Mass Protease 7 (LMP7) with Vitiligo in North India: case-control study. British Journal of Dermatology. 2018 Feb;178(2):482-491.
- Sharma A. & Rani R. Do we really need to differentiate Mesenchymal Stem Cells into Insulin producing cells for attenuation of autoimmune responses in Type 1 Diabetes : Immunoprohpylactic effects of precursors to insulin producing cells. Stem Cell Research & Therapy, 2017 Jul 12;8(1):167.
Reviews
- Piñón Hofbauer J, Guttmann-Gruber C, Wally V, Sharma A, Gratz IK, Koller U. Challenges and progress related to gene editing in rare skin diseases. Adv Drug Deliv Rev 2024;208:115294.