Studies on a drug that is used e.g. in patients with arthritis, revealed its impact on multiple miRNAs. One of them is miR-10b which plays an important role in metastasis and is present at increased levels in RDEB tumors.The aim of this project is to find out if a treatment with this drug will decrease the level of miR-10b and thereby lower the aggressiveness of RDEB-SCC cells in vitro. Upon dose finding in a first step, we will next determine the level of miR-10b. Also, we will use 3D-tumor models to determine the invasive potential of the cells upon treatment with the small molecule, and what effect it has on cell proliferaiton.
In my free time I like to spend my time with my friends, read or paint. But what I love most is travelling and experiencing new things.
Curriculum Vitae Caroline Fehringer
Bachelor studies: “Medical and Pharmaceutical Biotechnology”, IMC Krems