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Junctional Epidermolysis bullosa (JEB)

Junctional Epidermolysis bullosa (JEB) is an umbrella term for all forms of EB, in which the blisters are formed precisely in the connective segment between the outer most skin layer/epidermis and corium/dermis.

"Junctional" comes from the Latin word "iunctio", which means something like "connection". This joining segment is also referred to as the basement membrane.

Important points in a nutshell

  • Junctional Epidermolysis bullosa (JEB) is an umbrella term for all forms of EB, where the blister formation occurs wihtin the joining segment of the epidermis and dermis.
  • JEB is caused by mutations in different genes, and the various forms differ significantly from one another.
  • In addition to the blisterin of the skin, there are usually additional problems.
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